in vivo-jetPEI® is a ready-to-use cationic polymer reagent recommended for in vivo transfection of DNA, siRNA, miRNA, shRNA and other oligonucleotide...
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RNA/DNA Therapeutics
Ready-to-use lipid-based nanoparticles solution for in vivo mRNA delivery
Efficient
100% mRNA encapsulation leading to delivery efficiency comparable to LNPs
Time-saving
Ready-to-use reagent requiring no equipment or formulation expertise
Safe
Keep animals and organs healthy and triggers no/low pro-inflammatory response
Universal
Suitable for mRNA, saRNA, gRNA delivery via any administration route
Stable
Nanoparticle size and transfection efficiency are stable for 1 month when stored at 4°C
Type | Ready-to-use lipid-based nanoparticles |
---|---|
Molecule delivered | mRNA, saRNA, gRNA |
Biodistribution & Injection routes | Universal biodistribution: Any organ or tissue (depending on the injection route) |
Number of injections in mice | 1 mL is sufficient to perform 50 intravenous injections or 100 intramuscular injections in mice |
Storage | Store in vivo-jetRNA®+ at 5 ± 3°C. Do not freeze. |
Provided with | mRNA buffer |
in vivo transfection reagents are the most powerful alternative to viral vectors for nucleic acid delivery. They are easy to use, cost-effective and considered as safe and efficient vehicles for RNA delivery. mRNA transfection is rapidly emerging as a promising method for nucleic acid-based therapy and offers an attractive substitute to plasmid DNA. Non-viral mRNA delivery methods have already proven their efficiency in vaccination through antigen presenting cells modification and in anti-cancer therapy by directly targeting malignant cells. The intrinsic advantage of mRNA-based immunotherapy relies on the self-adjuvant activity of mRNA and the fact that small amounts of encoded antigen are sufficient to obtain robust immune response.
in vivo-jetRNA®+ is a non-viral delivery solution composed of pre-formed lipid-based nanoparticles. It was specifically developed for in vivo mRNA delivery. Its high delivery efficiency combined with its safety make in vivo-jetRNA®+ an innovative alternative to lipid nanoparticles (LNPs), with the added advantage of being user-friendly with a 2-step protocol.
in vivo-jetRNA®+ can be used to deliver mRNA, saRNA and gRNA via systemic or local administration routes in various animal models, making it an ideal tool for scientists developing vaccines, protein replacement therapies, performing oncology studies, or working on genome editing.
Next generation lipid-based delivery for mRNA therapeutics: in vivo-jetRNA®+
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Search for publications in our Transfection Database with Polyplus transfection reagents
This lexicon will help you to understand the different terms related to Polyplus-transfection®.